The Study of Correlation Structures of DNA Sequences:
A Critical Review
W. Li
Computer & Chemistry ,
(special issue on open problems of computational
molecular biology),
21(4), 257-272 (1997)
Abstract
The study of correlation structure in the primary sequences of DNA
is reviewed. The issues reviewed include: symmetries among 16
base-base correlation functions, accurate estimation of correlation
measures, the relationship between 1/f and Lorentzian spectra,
heterogeneity in DNA sequences, different modeling strategies of the
correlation structure of DNA sequences, the difference of correlation
structure between coding and non-coding regions (besides the period-3
pattern), and source of broad distribution of domain sizes. Although
some of the results remain controversial, a body of work on this
topic constitutes a good starting point for future studies.
