Study of Correlations in Segmented DNA Sequences:
Application to Structure Coupling between Exons and
Introns
V. R. Chechetkin, V. V. Lobzin
Journal of Theoretical Biology,
190 (1), 69-83 (January 7, 1998)
Abstract
A technique for the study of correlations in segmented DNA sequences is
developed. Within this approach the effects of compositional patchiness are
separated from the beginning, allowing us to display the refined effects of
structural coupling between different segments. The mutual analysis of
Fourier structure spectra and pair correlation functions identifies both the
main ranges (long, short, or intermediate) and the sources (coincident
periodicities, large scale density variations, short-memory coupling, or
coherent point mutations) of correlations. A scheme is applied to the study of
structural coupling between exons and introns in fragmented genes of
eukaryotes. The molecular, genetic, and evolutionary aspects of the features
observed are discussed.
