Detection of Latent Sequence Periodicities
E Pizzi, S Liuni, C Frontali
Laboratorio di Biologia Cellulare, Istituto Superiore di Sanit`a, Rome, Italy.
Nucleic Acids Research,
18(13), 3745-3752 (1990)
Abstract
A method is proposed for the automatic detection of serial periodicities in a linear
sequence. Its application to DNA subtelomeric sequences from two lower
eukaryotes, P.falciparum and S.cerevisiae, reveals ordered patterns organised in
hierarchical periodicities, not easily recognizable by other methods. The possible
implications concerning the evolution of tandemly repetitive arrays are discussed
in light of a model which involves, as successive steps, random repeat
modification, the fusion of differently modified repeat versions into longer units,
and the amplification of (and/or homogenization to) the more recent repeat unit
