Patchiness and correlations in DNA sequences

Samual Karlin, Volker Brendel

Science 259, 677--680 (January 29, 1993)

Abstract

The highly nonrandom character of genomic DNA can confound attempts at modeling DNA sequence variation by standard stochastic processes (including random walk or fractal models). In particular, the mosaic character of DNA consisting of patches of different compositional can fully account for apparent long-range correlations in DNA.

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