Transcription Regulatory Region Analysis Using Signal Detection and Fuzzy Clustering

L.Pickert, I.Reuter, F.Klawonn1 and E.Wingender

Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany and
1 Fachbereich Elektrotechnik und Informatik, Fachhochschule Ostfriesland, Constantiaplatz 4, D-26723 Emden, Germany

Bioinformatics, 14(3), 244-251 (April 1998)

Abstract

Motivation: Presently available programs for the recognition of potential transcription factor binding sites in genomic sequences generally yield a huge amount of output. These output lists have to be filtered to obtain biologically significant elements, which is highly laborious work to be done manually.

Results: We developed a strategy for systematic verification and improvement of the underlying profiles, and for their contextual analysis by a fuzzy clustering approach using non-redundant libraries of search profiles as a prerequisite.

Availability: The tools mentioned in the paper are available upon request. Contact: ewi@gbf.de