Searching for Regulatory Elements in Human Noncoding
Sequences
L Duret, P. Bucher
Laboratoire de Biometrie, Genetique et Biologie des Populations,
CNRS Universite Claude Barnard, Villeurbanne, France.
duret@biomserv.univ-lyon1.fr
Current Opinion in Structural Biology
7(3), 399-406 (Jun 1997)
Abstract
Important progress has been made in the past two years in
the identification of Pol II promoters. For most other
regulatory elements, however, current biological knowledge
is still insufficient to allow the development of prediction
tools. The phylogenetic-footprinting strategy, which is
based on the comparative analysis of homologous sequences,
is a very efficient approach to identify new unknown
regulatory elements. The recent organization of large-scale
sequencing projects for some model vertebrate organisms
will be extremely valuable for the prediction of regulatory
elements in the human genome.
