Finding the Genes in Genomic DNA
Christopher B Burge, Samuel Karlin
Current Opinion in Structural Biology
8:346-354 (1998)
Abstract
Genome sequencing efforts will soon
generate hundreds of millions of bases of
human genomic DNA containing thousands of
novel genes. In the past year, the accuracy of
computational gene-finding methods has
improved significantly, to the point where a
reasonable approximation of the gene
structures within an extended genomic region
can often be predicted in advance of more
detailed experimental studies.
