ORFs and genes: how strong a connection?
James W. Fickett
Journal of Computational Biology, 2(1):117-123 (1995)
Abstract
The length of an open reading frame (ORF) is one important
piece of evidence often used in locating new genes, particularly
in organisms where splicing is rare. However, there have been
no systematic studies quantifying the degree of correlation
between length of ORF, on the one hand, and likelihood of gene
function, on the other. In this paper, techniques are derived
to estimate the conditional probability of gene function, given ORF
length, based on evidence both from the databases and from simulation.
Several complete chromosomes of 