A Prevalent Persistent Global Nonrandomness That
Distinguishes Coding and Non-coding Eucaryotic Nuclear DNA Sequences
B.E. Blaisdell
Journal of Molecular Evolution(USA),
19(2):122-133 (1983).
Abstract
Coding sequences of eucaryotic nuclear DNA were characterized
by an excess of short runs and a deficit of long runs of weak and
of strong hydrogen bounding bases; non-coding sequences by a
deficit of short runs and an excess of long runs, in the same of
purines and of pyrimidines. The conservation of these attributes
across DNA sequences coding for proteins of widely different
function, across widely different eucaryotic species for the same
protein and across related genes that diverged a long time ago
and that now show large differences in base and, if coding, amino
acid sequence suggested that these attributes have survival value.
It was concluded that these attributes constitute probalistic
constraints on the primary structure (base sequence) of both
coding and non-coding DNA.
