Objective Comparison of Exon and Intron Sequences by Means of
2-dimensional Data Analysis Methods
L. Bougueleret, F. Tekaia, I. Sauvaget, J.M. Claverie
Nucleic Acids Research, 16(5):1729-1738 (Mar 11, 1988 )
Abstract
Here we advocate the use of 2-dimensional data representation in the
context of the informational approach of sequence analysis (Claverie
& Bougueleret (1986) Nucleic Acids Research 14, 179-196) by applying
these methods to the problem of intron/exon discrimination. Two main
findings are reported: i) oligonucleotide patterns complementary to
the Ul small nuclear RNA are specifically avoided in exon sequences,
ii) vertebrate intron sequences, to the exclusion of other
eukaryotic phyla, are characterized by a peculiar distribution of
CpG containing patterns.
