TDT with Covariates and Genomic Screens with Mod Scores: Their Behavior on
Simulated Data
J.P. Rice, R.J. Neuman, S.L. Hoshaw, E.W. Daw , C. Gu
Genetic Epidemiology ,
12(6), 659-664 (1995)
Abstract
We describe an extension to the TDT (transmission/disequilibrium test)
which allows for more than two marker alleles and for covariates measured on the
parent or offspring. We also describe a systematic genomic search where the mod
score (maximized lod score) is computed for each marker under constraints on the
population prevalence or penetrances of a single locus.
Association Studies