Sib-based Detection of QTLs
B.K. Suarez, C.L. Hampe, D. O'Rourke, P. Van Eerdewegh, T. Reich
Genetic Epidemiology, 12(6),675-680(1995)
Abstract
Association and transmission/nontransmission analyses were used in a split
sample design to identify disease susceptibility alleles at two loci. Sib-pair analysis on
various subsets of the data identified an additional four regions that yielded signals of disease
predisposing quantitative trait loci (QTLs). Three of these four regions represented Type I
errors. A new simulation indicates that a multiplex sampling strategy would substantially
improve QTL detection for this oligogenic transmission model.
Association Studies