A Haplotype-based 'Haplotype Relative Risk' Approach to Detecting Allelic
Associations
J.D. Terwilliger, J. Ott
Human Heredity ,
42(6), 337-346 (1992)
Abstract
A novel variation of the Haplotype Relative Risk (HRR) of Rubinstein et al.
[Hum Immunol 1981;3:384] is proposed, in order to glean increased information about
linkage disequilibrium or allelic associations by analyzing haplotype-based data rather
than genotypic data. It is shown that statistical tests based on our design give much higher
power than those based on the original HRR approach. Several additional nonparametric
tests based on the same data are analyzed, and power is computed for each of them.
Further, parametric likelihood methods are applied to testing linkage equilibrium, and
estimating delta, the coefficient of linkage disequilibrium, from the same data.
Association Studies