A Transmission Disequilibrium Test for Quantitative Trait Loci
D. Rabinowitz
Human Heredity ,
47(6), 342-350 (1997)
Abstract
The transmission disequilibrium test uses association between
marker alleles and dichotomous traits for precise genetic mapping
while avoiding confounding due to population admixture. Here,
the methodology is generalized from dichotomous traits to
quantitative traits. The generalization is computationally
straightforward and may be used with multiple alleles and with
siblings. Parametric assumptions on the distribution of
the quantitative traits are not needed. Environmental and
demographic covariates may be incorporated into the
analysis. The results of simulation studies that provide
information about the power of the approach are reported.
Association Studies