The Application of Shannon Entropy in the Identification
of Putative Drug Targets
Stefanie Fuhrman,
Mary Jane Cunningham,
Xiling Wen,
Gary Zweiger,
Jeffrey J. Seilhamer,
Roland Somogyi
Biosystems, 55(1-3):5-14 (2000)
Abstract
A major challenge in the field of functional genomics is
the development of computational techniques for organizing
and interpreting large amounts of gene expression data.
These methods will be critical for the discovery of
new therapeutic drug targets. Here, we present a
simple method for determining the most likely drug
target candidates from temporal gene expression patterns
assayed with reverse-transcription polymerase chain
reaction (RT-PCR) and DNA microarrays.