Summary: standard single locus TDT Argument: < file name >
The 'tdt' command performs the traditional Transmission Disequilibrium Test (Spielman, McGinnis, and Ewens, Am J Hum Genet. 1993 Mar;52(3):506-16.) on the Linkage-style pedigree file specified as the argument. Transmissions from homozygous parents are not counted (the obligately provide a transmitted and untransmitted copy of the same allele) and cases where one parent is missing are used only when the genotyped parent and the proband are both distinct heterozygotes (Curtis and Sham, Am J Hum Genet. 1995 Mar;56(3):811-2.) In addition, the transmissions and non-transmissions are stored for use by multi-locus TDT commands (tdt2, tdt3, tdt4). The case where the both parents and the proband have the same heterozygous genotype are counted (as a transmission and non-transmission of each allele) but are not stored for use in the multi-locus test.